Oral clindamycin should be administered with a full glass of water (to avoid esophageal irritation) and may be taken with or without food. Intramuscular doses should be administered as a deep IM injection. The concentration of clindamycin in diluent for IV infusion should not exceed 18 mg/mL. Premixed Clindamycin in 0.9% Sodium Chloride Injection is for intravenous infusion using sterile equipment. Check for minute leaks prior to use by squeezing bag firmly. Clindamycin and dextrose combination injection is used to treat bacterial infections in different areas of the body. This medicine is given to patients who had an allergic reaction to penicillin. Medscape - Infection-specific dosing for Cleocin (clindamycin), frequency-based adverse effects, comprehensive interactions, contraindications, pregnancy & lactation schedules, and cost. For most infections, oral clindamycin has approximately 90% bioavailability compared to intravenous administration, allowing for a straightforward conversion from IV to oral therapy with minimal dosage adjustments. 1 When inducible, the organism (most commonly S. aureus) will be resistant to macrolides but susceptible to clindamycin in vitro. Treatment with clindamycin can lead to treatment failures. However, this can be avoided by confirming susceptibilities in the laboratory using the D-zone tes t. Dilute each dose of clindamycin in 5 ml/kg of 0.9% sodium chloride or 5% glucose in children less than 20 kg and in a bag of 100 ml of 0.9% sodium chloride or 5% glucose in children 20 kg and over and in adults. Clindamycin Injection package insert / prescribing information for healthcare professionals. Includes: indications, dosage, adverse reactions and pharmacology. Type: Other antibiotic Dosage Forms: IM, IV, PO (75mg; 150mg; 300mg; 75mg/5mL) Common Trade Names: Cleocin Adult Dosing General PO: 150-450mg PO q6h First Dose: 150-450mg PO x 1 Max: 450mg/dose PO (increased risk of C. diff at higher doses) IM: 1200-2700mg/day IM divided q6-12h First Dose: 600mg IM x 1 Max: 600mg/dose IM IV 1200-2700mg/day IV. Cleocin I.V. (Clindamycin) may treat, side effects, dosage, drug interactions, warnings, patient labeling, reviews, and related medications including drug comparison and health resources.